ZD 7155 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZD 7155 hydrochloride是血管紧张素II受体1型 (AT1 receptor) 拮抗剂。

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

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In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.

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Endocrinology/Hormones

RAAS

RAAS

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146709-78-6

474.98

C26H27ClN6O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (526.33 mM; 超声助溶 ) H2O 中的溶解度 : 4.17 mg/mL (8.78 mM; 超声助溶 (<60°C))

Cl.CCc1cc2N(Cc3ccc(cc3)-c3ccccc3-c3nn[nH]n3)C(=O)CCc2c(CC)n1

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(-20℃)

With Ice Pack

≥ 2 years